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Accutane Side Effects: Should Depression Be A Concern?

Medical professionals and acne-pestered adolescents have no doubts about the effectiveness of the severe acne drug isotretinoin. It's the looming possibility of side effects such as depression and fetal damage that makes people uneasy when considering using this medication.

Five years earlier, in 2000, the isotretinoin-depression link still appeared misleading.

Accutane (isotretinoin) is one of Hoffman-LaRoche's most popular and controversial pharmaceuticals. This week, a study published in the Archives of Dermatology vindicated isotretinoin from causing depression. In this report, Christina Y. Chia, MD, from Saint Louis University Health Sciences Center, St. Louis, and colleagues examined whether patients with moderate to severe acne treated with isotretinoin experienced an increase in depressive symptoms compared with patients treated with a topical antibiotic, topical retinoid, and an oral antibiotic.

Dr. Chia found that "The use of isotretinoin in the treatment of moderate-severe acne in adolescents did not increase depressive symptoms. On the contrary, our study shows that treatment of acne improves depressive symptoms".

That time, the Archives of Dermatology posted study, headed by Dr. Susan S. Jick, from the Boston University School of Medicine, which found no evidence that isotretinoin increases the risk for depression, suicide, or other psychiatric disorders.

Even though isotretinoin finds ample support among dermatologists and psychiatrists, a host of parents, politicians and medical professionals hail isotretinoin as a medical misfortune.

For instance, Dr. David J. Graham, the Associate Director for Science and Medicine in FDA's Office of Drug Safety, recently warned that Accutane should be taken off the market. And while there are few studies with any negative observations about isotretinoin, Dr. Douglas Bremner's research at of the Emory University School of Medicine has linked isotretinoin treatment with changes in brain function. At the conclusion of this study, published in the American Journal of Psychiatry, Dr. Bremner concurred with Dr. Graham's view that isotretinoin proves too dangerous for human use. Dr. Bremner explains that to invoke depression, isotretinoin must influence the brain. During the investigation, brain function of the subjects was measured using positron emission tomography (PET) before and after four months of treatment with isotretinoin. Isotretinoin treatment was associated with decreased brain metabolism in the orbitofrontal cortex- the area of the brain known to mediate symptoms of depression. Yet, there were no differences in severity of depressive symptoms between the isotretinoin and antibiotic treatment groups before or after treatment.

The pessimistic effects of isotretinoin also caught the attention of Diane K. Wysowski PhD. Dr. Wysowski noted that in June 2000, isotretinoin ranked among the top 10 drugs linked to depression and suicide attempts in the FDA's Adverse Event Reporting System database. In 2001, Dr. Wysowski examined isotretinoin's depression inducing potential and posted her findings in the Journal of the American Academy of Dermatology. Dr. Wysowski concluded that more studies of isotretinoin are needed.

She also advised patients and their parents to immediately report mood swings and symptoms that are suggestive of depression such as sadness, crying, loss of appetite, unusual fatigue, withdrawal, and inability to concentrate to their prescribing physician. These protective measures can avoid more serious side effects and permit appropriate treatment, including consideration of drug discontinuation and referral for psychiatric care.

While dissension among researchers still exists about whether or not isotretinoin causes depression, one idea most of them can agree on is that more research on the side effects of isotretinoin are desirable. If you are not in the mood for being an isotretinoin guinea pig, Geoffrey Redmond MD, author of The Good News about Women's Hormones, suggests using hormone therapy and/or using Retin-A if isotretinoin seems too chancy for you.

 

Health author and Stanford University graduate Naweko San-Joyz lovingly writes from her home in San Diego. Her works include "Acne Messages: Crack the code of your zits and say goodbye to acne" (ISBN: 0974912204) and the upcoming work "Skinny Fat Chicks, Why we're still not getting this dieting thing" (ISBN: 0974912212) for release in June of 2005. For useful acne self-help articles visit http://www.Noixia.com

 

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Depression Glass Trivia

 

Depression glass facts make for interesting conversation, especially when you're at a convention or talking amongst other Depression glass aficionados. So here are a few items to get you started so you, too, can have some meaningful knowledge to put on the plate when you and your Depression glass collector friends gather 'round and chat.

English Hobnail leads the pack as the design with around the most available pieces still out there for collectors. Westmoreland Glass Company produced the English Hobnail pattern from the late 1920s to the 1980s, with the Depression-era pieces made in eight different colors. In total, 175 pieces of this particular design were created.

Rose Cameo, conversely, holds the record for the least number of pieces available in a pattern. The Belmont Tumbler Company held the patent for Rose Cameo, and only six pieces of this design made it to the marketplace: a plate, a footed sherbet, a footed tumbler, a berry bowl, and a 5-inch and 6-inch bowl. Because Belmont manufactured only tumblers and was trying to recover from a massive fire, experts speculate the actual production of this rare design happened at the Hazel-Atlas Glass Company, only a few miles away. A six-piece set of tumblers - the pattern was only made in green - in mint condition can be had for between $150 and $175 (prices may have changed since I wrote this).

Of the 200+ patterns of Depression glass created, footed salt and pepper shakers from Hocking's Mayfair design demand some of the very highest prices. Don't flinch when (or if) you have a close encounter with one: They go for more than $9,000, which makes them 1 of the most expensive items of all Depression glass patterns at the time of writing this article.

Hazel-Atlas produced the Aurora pattern in beautiful cobalt blue for one year only - from 1937 to 1938.
Jeanette and Federal glass companies manufactured the two most reproduced patterns, Cherry Blossom and Madrid. Jeanette produced 43 pieces of the Cherry Blossom design from 1930 to 1939 in five colors. Federal's Madrid output numbered 45 pieces in five colors from 1932 to 1939. The popularity of these designs, of course, made reproductions impossible to avoid, but also makes the original Depression-era versions that much harder to detect.

This article, perhaps, may inspire you to dig deeper and find out even more about the Depression glass products we've all come to love. Hopefully, with these bits and pieces of trivia, you've learned something you didn't already know. If you haven't, then you need to be writing your own articles on Depression glass trivia and enlightening the rest of us! But if you have benefited, you can safely know that the next time you're sitting next to that 40-year collector at convention, you, too, have more comments to make than just about "all those pretty, Depression glass colors!"

Until next time,
Murray Hughes http://www.DepressionGlassSecrets.com
http://www.depressionglasssecrets.com/DPweb-articles/depression-glass-trivia.htm

 

If you enjoyed this article by Murray Hughes, then visit http:www.//DepressionGlassSecrets.com now and enroll in the free Depression Glass course "The 5 Essential Steps To Becoming A Depression Glass Collector"

 

Is There Money To Be Made In Depression Glass

 

You've seen the shows on television. You've watched the auctions online. You've read the stories in the newspaper.
There always seems to be someone somewhere with an old dish they've found in the corner of their attic that they were just about to throw away or donate to a thrift shop when someone advised them to have an expert take a look at it, or to put it up for auction online, or to place it somewhere for whatever you can get as long as it pays for your advertisement. And lo and behold! What they thought was fodder for the trash can or Goodwill turns out to be the rarest piece of glassware this side of the Atlantic, and they've not only paid for their advertising - they've got no more financial worries for the remainder of their lives!

 

The Jeanette Glass Company breaks all records for coming up with the most patterns. Jeanette made 11 patterns of Depression glass between 1928 and 1946: Sunburst, Homespun, Swirl, Doric and Pansy, Windsor, Sunflower, Doric, Adam, Sierra, Floral, and Cherry Blossom. And then at the other end of the spectrum, the Fenton Glass Company produced only a single pattern of Depression glass - the Lincoln Inn.


Hearing such a story, I can guarantees it was not Depression Glass. While money can be made, given it was mass produced by many companies for a number of years and can still be bought and sold in many locations, it may be another couple of hundred years before a single piece can put you on easy street!

But the very fact that professional dealers exist is an indication that money can be made in the buying and selling of Depression Glass. And knowing the value of each piece in your collection can have other purposes.

There are times when knowing what your pieces are worth serves a practical purpose. Suppose your agent needs to know for loss-coverage purposes. Or maybe you've decided to get out of the Depression glass hobby and need to know an intelligent amount to place on your Depression glass pieces before you put them on the market. Or someone wanting to purchase a piece may approach you, and you need to know what amount to accept. Conversely, you may also be interested in acquiring a piece and need to have some idea of an amount that won't sound ridiculous. These are all valid reasons to know what your Depression glassware will bring on the current market. And that's the rub - the current market.

The current market is relative to several things, which make price-guide books just that - guides. The best books can only give us ballpark figures because so many other things affect what we can or can't get for a piece of Depression glass. Where in the country -- or the world -- you're located, the supply and demand for whatever piece or pieces you're buying or selling, and, of course, the rarity and condition of the glassware you're interested in - all these factor in to determine current market conditions.

Another thing to always remember is this bottom line: Anything - whatever it may be - is worth whatever you are willing to give for it or to sell it for. It all boils down to how badly you want that Blue Ritz Royal Lace piece - or how badly you want to get rid of it.

So go ahead and get your hands on the most current guidebook. Study up on what people are giving and getting for pieces you're interested in. Talk to an expert, if you can. Afterward, use that information as a tool and a guideline, only. And then go purchase or sell that Depression glass piece and get your feet wet in the marketplace.

There's no greater teacher than experience! Until next time,
Murray Hughes http://www.DepressionGlassSecrets.com
http://www.depressionglasssecrets.com/DPweb-articles/selling-depression-glass.htm

 

If you enjoyed this article by Murray Hughes, then visit http:www.//DepressionGlassSecrets.com now and enroll in the free Depression Glass course "The 5 Essential Steps To Becoming A Depression Glass Collector"

 

Depression Glass Patterns

Collectors of Depression Glass find not only its beautiful colors fascinating, but its patterns, as well. With many glass producers making this type of glass, as you can imagine, many patterns resulted, creating a wide array of pretty, practical, and inexpensive glassware affordable to every American household in that lean era of history and making Depression Glass one of the most collectible items today.

Of the many glass manufacturers that produced Depression Glass, seven of them became major players in the field, creating a total of 92 designs. Below you'll find some history, some trivia, some folklore, and some interesting characteristics about several of these designs.

Pattern: Cameo
This Depression Glass design, sometimes referred to as Ballerina or Dancing Girl, gets its name from the tiny dancer found on all its pieces. Some claim the Hocking Glass Company that manufactured Cameo glass created the pattern to honor the legendary modern dancer of the 1920s, Isadora Duncan, who tragically died when her long trailing scarf, of which she'd made her personal trademark, choked her to death when it wrapped around the wheel of her moving Bugatti roadster.

Duncan died in 1927, and the Cameo pattern came into being in 1930, continuing to be produced until 1934, so the story could very well be true. Regardless of the inspiration for this pattern of Depression Glass, it continues as a much sought-after design. Hocking made most Cameo glass in green, but pink, yellow, and - more rarely - crystal, which can occasionally still be found.

Pattern: Avocado
First produced in 1923, the Avocado or "Sweet Pear" pattern claims its fame for being the very first 'true' Depression Glass design. Made by the Indiana Glass Company, Avocado pieces in the form of pitchers prove to be the most difficult to find, possibly because of this pattern's age. Indiana continued manufacturing Avocado for 10 years, until the company retired this Art Nouveau-type design in 1933.

Pattern: Royal Lace
The Hazel-Atlas Glass Company began producing Royal Lace during 1934 as a set consisting of 28 pieces. Today, Royal Lace holds the honor of being some of the costliest Depression glass that collectors covet. Hazel-Atlas manufactured Royal Lace in crystal (clear) and in five colors: green, yellow, pink, blue, and burgundy. The most desirable color consistently proves to be the blue, called Ritz Blue by the company, which actually came about as an economic accident.

When General Mills ended a deal with Hazel-Atlas' using blue-colored glass in a Shirley Temple promotional campaign in 1936, Hazel-Atlas simply poured the leftover vats of molten blue glass into its existing Royal Lace molds to avoid wasting it. An instant success resulted. Blue Royal Lace Depression Glass reigns to this day as 1 of the most sought after and is now 1 of the most expensive of all the other Depression Glass patterns.

These samplings of interesting Depression Glass trivia make collecting it all that more appealing. After all, how many other pieces of glassware can be found in people's homes that come with a ready-made story - at least those people in the median income range (We're not talking Tiffany or Lalique here!)? And these have been gleaned from a mere sampling of the plethora of Depression Glass designs that have survived over the years. Imagine what stories can be found!

The next time you gaze at that lovely piece of Depression glass resting in the window of your favorite antique dealer or - if you're lucky - sitting on a dusty shelf at a flea market just waiting for you to discover it, remember: Whatever pattern it is, a good chance exists that it, too, will have a fascinating history.

So take a chance. Buy it! Until next time,
Murray Hughes http://www.DepressionGlassSecrets.com
http://www.depressionglasssecrets.com/DPweb-articles/depression-glass-patterns.htm

 

If you enjoyed this article by Murray Hughes, then visit http:www.//DepressionGlassSecrets.com now and enroll in the free Depression Glass course "The 5 Essential Steps To Becoming A Depression Glass Collector"

 

Collecting Depression Glass - Where to Start.

 

Okay, so you've been bitten by the Depression Glass bug, and those pretty patterns and pastel colors beckon you from the shelves of an antique dealer's shop, a friend's home, or maybe you've even discovered this special glassware on the Internet. How ever it's come about that you've developed a yen for Depression Glass, you need to know where and how to start collecting it - unless you're made of money, have oodles of time on your hands, and don't care whether you get the real thing or not. But if you're like most of us, and those things don't apply to you, here are a few tips to get you started on the road to what may very well become a fascinating and lifelong hobby.

Step 1 -

Buy the latest edition of the book, The Collector's Encyclopedia of Depression Glass by Gene Florence that boasts a recommendation from the National Depression Glass Association. Mr. Florence's comprehensive book covers all the known patterns with photographs and current price listings, short histories of the manufacturers, information on detecting fakes and reproduction pieces, along with the production dates and colors of each design. All this, including the author's own personal anecdotes about this addictive hobby, make this book not only one of the most useful tools from which to learn about Depression Glass, but turns learning about the subject into entertainment, as well.

Step 2 -

Go to glass shows and conventions, join Depression Glass clubs, and visit antique shops in your area that carry it. It's imperative to learn about this type of glass from hands-on knowledge in order to get a true feel of how it looks "in person." Soon you'll learn many, if not all, the colors and patterns, and be able to distinguish reproductions - most commonly made in Mexico and India - from the genuine article. Color, patterns, weight, mold markings - even the bubbles - of real Depression Glass hold a uniqueness all their own.

 

As always, it is important to look at things holistically. Emotional aspect must consider. Often depression comes with an overload of energy, so releasing that energy is important. So apart from exercise already mentioned, massage is a great energy mover. Doing things that help spark your creativity can help release pent up emotional energy too. Consider writing in a journal, or stories, poetry, whatever. Drawing pictures, they don't have to be a master pieces, just let yourself go, draw squiggles, doodle, paint picture, splurge with colour. Take a class in something like pottery, anything creative. Play a musical instrument. Sing. It doesn't have to be in tune, just let it out; this is a great way to release emotions. Enjoy other people's creativity; go to museums, art galleries, craft show, or concerts.


Step 3 -

Subscribe to magazines, newsletters, and other periodicals that focus on collecting Depression Glass. The National Depression Glass Association offers an online newsletter subscription on its site at www.ndga.net, and Collector's News, a print magazine, frequently features articles of interest to Depression Glass fans.

Step 4 - Meet and make friends with an expert! There's nothing like having a mentor to guide you when you're in the process of learning something new - especially about Depression Glass. Such tips as learning to use your tactile sense of feel to detect chips and cracks, holding a piece up to the light to help determine its authenticity, and other helpful information usually come from personal relationships. Attending shows, joining clubs, and visiting antique shops all provide opportunities to make friends with people who've been involved in collecting Depression Glass - some for as long as 40 or 50 years.

The most important thing to remember when you begin your Depression Glass hobby, however, is to have fun! Even if you do make a mistake, get occasionally "rooked" with a fake, or buy or sell something you later regret, you'll always have the experience of appreciating an interesting and fascinating hobby. And then, when you do make the find of your life - well, that's what it's all about! All those "mistakes" soon become laughable, fond memories when you proudly display your wonderful Depression Glass discovery!

So get out there and make your start today or look for the next beautiful piece to add to your growing collection.

Until next time,
Murray Hughes http://www.DepressionGlassSecrets.com
http://www.depressionglasssecrets.com/DPweb-articles/collecting-depression-glass.htm

 

If you enjoyed this article by Murray Hughes, then visit http:www.//DepressionGlassSecrets.com now and enroll in the free Depression Glass course "The 5 Essential Steps To Becoming A Depression Glass Collector"

Beating Depression

Depression hits many of us at different times during our lives. The symptoms are commonly known: being tired all the time, low self-esteem, no self-confidence, disturbed sleep, concentration impaired and no interest in life.

Depression is not just a dark mood; it is an illness. Low levels of the hormone serotonin are a known contributing factor. The lower the Serotonin levels the deeper the depression. To increase the Serotonin all the building blocks need to be present. One of the vital missing links is often the amino acid Tryptophan. So increasing Tryptophan in our diets can help ease depression. Foods that are high in Tryptophan are fish, turkey, meat and chicken, Parmesan cheese, almonds, barley, lentils and bananas. Tryptophanes first priority in the body is to make Niacin (vitamin B3), not to make Serotonin. In other words, it is vital to ensure that you are getting adequate amounts of Niacin in your diet, if you are going to increase the Serotonin levels. Other B Vitamins are also essential. A good balance diet, which includes a variety of fish, pulses and fresh raw vegetables, is always the key.

Some foods that help lift moods are:
Carbohydrates in winter, if you crave these in winter, they may help lift the winter blues. Look towards eating the more complex carbohydrates such as dried beans, pasta, vegetables, cereal, whole grain bread and crackers.

Spinach is high in folic acid. It has been shown that people with depression have lower levels of folic acid than normal. Low folic acid can cause the levels of Serotonin to shrink. The amount need to fight off depression is only 200mg-500mg a day. This amount can easily be found in foods such as green leafy vegetables. 200mg is can be obtained from about three quarters of a cup of spinach.

Fish is brain food. Eating seafood can improve your mood. Seafood is extra high in the trace mineral Selenium. Those with low Selenium levels are more likely to be anxious, depressed and tired. (Australian soils are deficient in Selenium) It has been found that when those with low Selenium levels increase them, their moods improve. Most Selenium comes from grains, seafood and cereals. Brazil nuts are one of the richest sources of them all. Eating just one a day will guarantee you are never deficient in Selenium.

Garlic. Studies on garlic have shown that not only do they have other health benefits, but also the garlic eaters, generally had a greater sense of well-being. They experienced less fatigue, anxiety, sensitivity, agitation and irritability.

Many lifestyle considerations need to be looked in to. Smoking cigarettes and drinking alcohol can decrease the tryptophan levels, as can caffeine and sugar. When suffering from depression it is easy to use these as a crutch and instead of decreasing your usage, it is increased. Of course this just exacerbates the situation.

Exercise is a great mood lifting. Mood elevating endorphins are released during exercise. A brisk walk or jog is great way to clear the air. Other great exercises for this are cycling, racquet sports, aerobic exercise, weight lifting, etc.

A great way to deal with depression is to get involved in something worthwhile. Leave your troubles behind and help someone else. In our lives today, it is so easy to become isolated from other people. This is just a breeding ground for depression. Join a group and make some friends. Find someone to talk to about your problems. In severe cases counselling may help.

If you need more than this you may want to consider supplements. Hypericum (St John's Wort) is the number 1 herb for depression. (If you are on other medication, check first that it won't interact) Tryptophan is available but on a limited basis. A multivitamin, which is high in the B vitamins, is essential. Flower Essences are a good stand by to help you through. Essential oils can also lift the mood. (If you would like help in selecting the right combination of supplements, just contact me through my website, http://www.puttingitright.com.au and I will put together a selection for you, with a special price.)

Above all, changing your outlook helps. Work on replacing your negative thoughts with positive empowering thoughts. Take charge and live the life you want to live.

 

Andrea Putting N.D., Naturopath, Writer and creator/owner of health sites including, http://www.puttingitright.com.au, http://www.naturopathsresourcefile.info, and http://www.naturalhealth4cats.info . Explore the world of Natural Medicine; take your health into your own hands. Know how to be healthy and stay healthy.

 

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